Adenosine permeation of a dynamic in vitro blood–brain barrier inhibited by dipyridamole
Identifieur interne : 003265 ( Main/Exploration ); précédent : 003264; suivant : 003266Adenosine permeation of a dynamic in vitro blood–brain barrier inhibited by dipyridamole
Auteurs : Christopher J. D. Sinclair [Canada] ; Ljiljana Krizanac-Bengez [États-Unis] ; Kathë A. Stanness [États-Unis] ; Damir Janigro [États-Unis] ; Fiona E. Parkinson [Canada]Source :
- Brain Research [ 0006-8993 ] ; 2001.
English descriptors
- KwdEn :
- Adenosine (antagonists & inhibitors), Adenosine (metabolism), Adenosine transport, Animals, Blood-Brain Barrier (physiology), Capillary Permeability (drug effects), Carrier Proteins (antagonists & inhibitors), Cattle, Cells, Cultured, Cellular and molecular biology, Dipyridamole, Dipyridamole (pharmacology), Dynamic in vitro blood–brain barrier, Models, Biological.
- MESH :
- chemical , antagonists & inhibitors : Adenosine, Carrier Proteins.
- chemical , metabolism : Adenosine.
- drug effects : Capillary Permeability.
- chemical , pharmacology : Dipyridamole.
- physiology : Blood-Brain Barrier.
- Animals, Cattle, Cells, Cultured, Models, Biological.
Abstract
Adenosine is an inhibitory neuromodulator in the central nervous system and has been reported to have neuroprotective properties. Using a dynamic in vitro blood–brain barrier, we investigated the hypothesis that inhibition of adenosine transporters on the lumenal side of the blood–brain barrier may decrease the loss of adenosine from the brain. Our results indicate that lumenal administration of dipyridamole, a nucleoside transport inhibitor, can inhibit adenosine permeation from the extracapillary space into the lumen.
Url:
DOI: 10.1016/S0006-8993(01)02175-8
Affiliations:
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Le document en format XML
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Parkinson</name><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E." last="Parkinson">Fiona E. Parkinson</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Krizanac Bengez, Ljiljana" sort="Krizanac Bengez, Ljiljana" uniqKey="Krizanac Bengez L" first="Ljiljana" last="Krizanac-Bengez">Ljiljana Krizanac-Bengez</name></region><name sortKey="Janigro, Damir" sort="Janigro, Damir" uniqKey="Janigro D" first="Damir" last="Janigro">Damir Janigro</name><name sortKey="Stanness, Kathe A" sort="Stanness, Kathe A" uniqKey="Stanness K" first="Kathë A." last="Stanness">Kathë A. Stanness</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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